WHAT ARE PEPTIDES?
Peptides are proteins, chains of amino acids the body produces naturally, which instruct the cells in our bodies on how to perform as well as acting as hormone and immune modulators.
There are over 7,000 different peptides controlling hundreds of biochemical processes in the body.
PEPTIDE THERAPY
Peptide therapy has been used as a less invasive, more natural alternative to support the body’s natural processes. The whole gamut comprises hundreds of peptides to be used and combined depending on the function and benefits desired.
Some of the most common benefits of peptide therapy are:
- Boosting the immune system
- Treating hypertension
- Enhancing sleep quality
- Sharpening memory and cognitive focus
- Improving cognitive focus and memory
- Increasing the libido
- Building muscle
PNC-27: an anti-cancer peptide
PNC-27 is a peptide that selectively disintegrates the membrane of cancer cells, promoting the death by necrosis of cancerous cells and primary tumors while being safe for healthy cells.
PNC-27 can kill multiple types of cancers
HOW DOES PNC-27 WORK?
One of the characteristics of cancerous cells is the elevated presence of the oncoprotein denominated HDM2; oncoproteins are proteins encoded with oncogenes. In other words, cancerous cells contain proteins genetically coded to cause cancer potentially.
The above-mentioned is why PNC-27 is so effective in disintegrating cancerous cells while being completely safe for healthy ones. The ability of PNC-27 to form pores and disintegrate the membrane of cells is tightly linked to its reaction to HDM2, which is very low, basically undetectable, in normal, healthy cells.
PNC-27 has no known side effects.
PNC-27 FAQ
- What is the principle behind PNC-27?
- What is PNC-27?
- How is the PNC-27 therapy given?
- What dose will be used?
- How does PNC-27 work in cancer cells?
- Could you provide studies that prove the efficiency of PNC-27?
- Does PNC-27 kill healthy cells?
- Bibliography
PNC-27, a 32-residue peptide that contains an HDM-2 binding domain and a cell-penetrating peptide (CPP) leader sequence which kills cancer, but not normal, cells by binding to HDM-2 associated with the plasma membrane and induces the formation of pores causing tumor cell lysis and necrosis.
PNC-27 is a peptide that selectively lyse the membranes of cancer cells. A peptide is a short chain of amino acids linked by chemical bonds. Among cells, peptides can perform biological functions, and PNC-27 has been studied for its anticancer applications.
Aside from the Intravenous solution, it can also be administered in a nebulized solution, or vaginal or rectal suppository.
PNC-27, a 32-residue peptide that contains an HDM-2 binding domain and a cell-penetrating peptide (CPP) leader sequence kills cancer, but not normal, cells by binding to HDM-2 associated with the plasma membrane and induces the formation of pores causing tumor cell lysis and necrosis.
Of course!
You can find this information in our biliography.
No, PNC-27 binds specifically to cancer cells because the HDM-2 oncoprotein is over expressed only in these cells, thus protecting normal cells.
- Forbes J, Krishnamurthy K. Biochemistry, Peptide. [Updated 2022 Aug 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK562260/
- Sarafraz-Yazdi, E., Mumin, S., Cheung, D., Fridman, D., Lin, B., Wong, L., Rosal, R., Rudolph, R., Frenkel, M., Thadi, A., Morano, W. F., Bowne, W. B., Pincus, M. R., & Michl, J. (2022). PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis. Biomedicines, 10(5), 945. https://doi.org/10.3390/biomedicines10050945
- Silberstein, M. (2020). Is PNC-27 and PNC-28 the Best way to cure Cancer?. The Science Journal of the Lander College of Arts and Sciences, 13(2). Retrieved from https://touroscholar.touro.edu/sjlcas/vol13/iss2/7
- Thadi, A., Lewis, L., Goldstein, E., Aggarwal, A., Khalili, M., Steele, L., Polyak, B., Seydafkan, S., Bluth, M. H., Ward, K. A., Styler, M., Campbell, P. M., Pincus, M. R., & Bowne, W. B. (2020). Targeting Membrane HDM-2 by PNC-27 Induces Necrosis in Leukemia Cells But Not in Normal Hematopoietic Cells. Anticancer Research, 40(9), 4857–4867. https://doi.org/10.21873/anticanres.14488
- Yu, G. W., Rudiger, S., Veprintsev, D., Freund, S., Fernandez-Fernandez, M. R., & Fersht, A. R. (2006). The central region of HDM2 provides a second binding site for p53. Proceedings of the National Academy of Sciences, 103(5), 1227–1232. https://doi.org/10.1073/pnas.0510343103